The first collaboration was in the film "Blue Velvet". Their collaboration continued in other films such as Wild at Heart, Inland Empire, and the TV series Twin Peaks. Lynch also worked with Dern on the TV series Twin Peaks, where she played the role of Diana Evans.

David Lynch and Kyle McLachlan are long—time creative partners. Their union began with Dune (1984), solidified in Blue Velvet (1986), and became iconic in Twin Peaks, where McLachlan became Lynch's on-screen alter ego. Their relationship is based on deep mutual understanding and a common artistic intuition.

The collaboration began with "Blue Velvet" (1986) and continued in "Twin Peaks", "Highway to Nowhere", "Mulholland Drive" and other projects. Badalamenti created atmospheric music, perfectly conveying Lynch's world. Their relationship was based on a deep understanding and synthesis of image and sound.

Nance starred in Lynch's debut, Eraser Head (1977), and later appeared in almost all of Lynch's films, including Blue Velvet, Dune, and Twin Peaks. They shared a creative understanding and personal friendship that lasted until Lance's death in 1996.

The relationship began during the filming of Blue Velvet (1986), where Rossellini played a key role. The relationship lasted for several years and strongly influenced both of them, combining personal and professional.